Using cryo-electron microscopy (cryo-EM), Lawrence Berkeley National Laboratory scientist Eva Nogales and her team have made a significant breakthrough in our understanding of how our molecular machinery finds the right DNA to copy, showing with unprecedented detail the role of a powerhouse transcription factor known as TFIID.
Scientists studying the human tissues and entire living model organisms have an array of tools at their disposal to view the inner workings of our biological systems, from mass spectrometry imaging and optical microscopies, which can make pictures of entire tissues and organs, down to X-ray crystallography and NMR (nuclear magnetic resonance), which can image
Berkeley Lab scientists have gained more insights into why older women are more susceptible to breast cancer. They found that as women age, the cells responsible for maintaining healthy breast tissue stop responding to their immediate surroundings, including mechanical cues that should prompt them to suppress nearby tumors.
Combining components of Rosetta and PHENIX, two successful software programs for creating 3D structural models of proteins and other biomolecules, Berkeley Lab researchers have created a new method for refining those models and making the best of available experimental data.
Berkeley Lab and University of Wisconsin researchers have created the first technique to offer full color IR tomography, a non-destructive 3D imaging process that provides molecular-level chemical information of unprecedented detail on biological and other specimens with no need to stain or alter the specimen.