News Center

Of Metal Heads and Imaging

IPI is a fluorescent probe that can visualize changes in exchangeable iron stores in living cells upon iron supplementation or depletion.

Berkeley Lab researchers are developing molecular imaging probes and techniques to study metals in the brain that have been linked to disorders such as Alzheimer’s and Parkinson’s diseases.

“Imaging Life” Crosses Biological Boundaries, Introduces Integrated Bioimaging

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Scientists studying the human tissues and entire living model organisms have an array of tools at their disposal to view the inner workings of our biological systems, from mass spectrometry imaging and optical microscopies, which can make pictures of entire tissues and organs, down to X-ray crystallography and NMR (nuclear magnetic resonance), which can image

New Clues to Why Older Women are More Vulnerable to Breast Cancer

These fluorescent images of human mammary epithelial cells exemplify the effects of aging. In the left image, multipotent progenitor cells from a 19-year-old young woman respond to a tumor-mimicking stiff surface by differentiating into red-colored tumor-suppressing myoepithelial cells. In the right image, progenitor cells from a 66-year-old woman fail to launch this putative cancer-fighting response when exposed to a stiff surface. (Credit: Pelissier/LaBarge)

Berkeley Lab scientists have gained more insights into why older women are more susceptible to breast cancer. They found that as women age, the cells responsible for maintaining healthy breast tissue stop responding to their immediate surroundings, including mechanical cues that should prompt them to suppress nearby tumors.

Bringing Out the Best in X-ray Crystallography Data

Combining components of Rosetta and PHENIX, two successful software programs for creating 3D structural models of proteins and other biomolecules, Berkeley Lab researchers have created a new method for refining those models and making the best of available experimental data.

3D IR Images Now in Full Color

Berkeley Lab and University of Wisconsin researchers have created the first technique to offer full color IR tomography, a non-destructive 3D imaging process that provides molecular-level chemical information of unprecedented detail on biological and other specimens with no need to stain or alter the specimen.

Tiny Bubbles Hold Big Promise for NMR/MRI

Tiny bubbles carrying hyperpolarized xenon gas hold big promise for greatly increasing the sensitivity of NMR/MRI technologies.

Of Aging Bones and Sunshine

Berkeley Lab researcher have shown that deficiencies in vitamin D – the sunshine vitamin – accelerates the aging of bone, reducing the quality and making it more susceptible to fracturing.

Cancerous Traffic Jams: Biomechanical Factor in Malignancies Identified

Berkeley Lab researchers have demonstrated that the malignant activity of a cellular protein system strongly linked to breast cancer can arise from what essentially are protein traffic jams.

Copper on the Brain

Berkeley Lab researchers have developed unique fluorescent probes for molecular imaging of copper in the brain, and are using these probes to uncover new information critical to a healthy mind.

Comparing Proteins at a Glance

A revolutionary X-ray analytical technique enables researchers at a glance to identify structural similarities and differences between multiple proteins under a variety of conditions and has already been used to gain valuable new insight into a prime protein target for cancer chemotherapy.