News Center

Scientists Discover Protein’s Starring Role in Genome Stability, and Possibly Cancer Prevention

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A protein called XPG plays a previously unknown and critical role helping to maintain genome stability in human cells. It may also help prevent breast, ovarian, and other cancers associated with defective BRCA genes.

New Weapon in the Fight Against Breast Cancer

184AA3, a xenograft model of ER+ breast adenocarcinoma, is the first clinically-relevant mouse model to generate tumors that bear a striking resemblance to the class of tumors found in the vast majority of women with breast cancer.

Berkeley Lab researchers have developed the first clinically-relevant mouse model of human breast cancer to successfully express functional estrogen receptor positive adenocarcinomas.
This model should be a powerful tool for testing therapies for aggressive ER+ breast cancers and for studying luminal cancers — the most prevalent and deadliest forms of breast cancer.

Nanocarriers May Carry New Hope for Brain Cancer Therapy:

3HM nanocarriers for brain cancer therapy

Berkeley Lab researchers have developed a new family of nanocarriers, called “3HM,” that meets all the size and stability requirements for effectively delivering therapeutic drugs to the brain for the treatment of a deadly form of cancer known as glioblastoma multiforme.

Berkeley Lab to Investigate Link between Thirdhand Smoke and Cancer

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Berkeley Lab researchers have been awarded $1.3 million for two sets of studies to better understand the health impacts of thirdhand smoke, the noxious residue that clings to virtually all indoor surfaces long after the secondhand smoke from a cigarette has cleared out.

Time-Lapse Analysis Offers New Look at How Cells Repair DNA Damage

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Time-lapse imaging can make complicated processes easier to grasp. Berkeley Lab scientists are using a similar approach to study how cells repair DNA damage. Microscopy images are acquired about every thirty minutes over a span of up to two days, and the resulting sequence of images shows ever-changing hotspots inside cells where DNA is under repair.

Berkeley Lab Scientists to Develop Better Way to Screen Chemicals for Cancer-Causing Effects

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Berkeley Lab scientists are developing a cell culture that could help researchers better identify chemicals that increase breast cancer susceptibility. The scientists will grow the culture using adult stem cells obtained from breast tissue. Their test will show if a chemical causes a breakdown in cell-to-cell communication, which is a fundamental defect of cancer.

New Clues About the Risk of Cancer From Low-dose Radiation

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Berkeley Lab scientists studied mice and found their risk of mammary cancer from low-dose radiation depends a great deal on their genetic makeup. They also learned key details about how genes and the cells immediately surrounding a tumor (also called the tumor microenvironment) affect cancer risk.

Grants Give Particle Accelerator Technologies a Boost

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Berkeley Lab researchers have won two grants from the DOE and NCI that focus on particle beam-based therapies for treating cancer as well as on building faster, more powerful lasers for accelerators.

For Important Tumor-Suppressing Protein, Context is Key

Illustration of p53 binding to major categories of repeats in the human genome, such as LTR, SINE and LINE.

Berkeley Lab scientists have learned new details about how an important tumor-suppressing protein, called p53, binds to the human genome. As with many things in life, they found that context makes a big difference.

Scientists Develop New Way to Study How Human Cells Become Immortal, a Crucial Precursor to Cancer

The left image shows the chromosomes of an immortal cell line derived by treatment with a chemical carcinogen. It has an aberrant number and arrangement of chromosomes. This line had to generate the errors that allowed immortalization. The right image shows the chromosomes of an immortal line derived using the new Berkeley Lab method. It has the normal number of 46 chromosomes arranged in 23 pairs. Because of their normal karyotype, these new immortal cell lines may help scientists better understand cell immortalization as it occurs in people. (Image credit: Arthur Brothman and Laura Fuchs, left image; Karen Swisshelm, right image).

Berkeley Lab scientists have developed a new method that can easily create immortal human mammary epithelial cells. The cells could greatly facilitate the examination of cell immortalization as it actually occurs during cancer progression.