Time-lapse imaging can make complicated processes easier to grasp. Berkeley Lab scientists are using a similar approach to study how cells repair DNA damage. Microscopy images are acquired about every thirty minutes over a span of up to two days, and the resulting sequence of images shows ever-changing hotspots inside cells where DNA is under repair.
Berkeley Lab scientists are developing a cell culture that could help researchers better identify chemicals that increase breast cancer susceptibility. The scientists will grow the culture using adult stem cells obtained from breast tissue. Their test will show if a chemical causes a breakdown in cell-to-cell communication, which is a fundamental defect of cancer.
Berkeley Lab scientists have gained more insights into why older women are more susceptible to breast cancer. They found that as women age, the cells responsible for maintaining healthy breast tissue stop responding to their immediate surroundings, including mechanical cues that should prompt them to suppress nearby tumors.
A consortium led by Berkeley Lab scientists has conducted the largest survey yet of how information encoded in an animal genome is processed in different organs, stages of development, and environmental conditions. Their findings, based on fruit fly research, paint a new picture of how genes function in the nervous system and in response to environmental stress.
Berkeley Lab scientist Sylvain Costes has come up with a way to automate the job of screening for DNA damage, using a proprietary algorithm and a machine to scan specimens and objectively score the damaged DNA. Now he has launched Exogen Biotechnology to commercialize the technology and, he hopes, make tests for DNA damage as common as a cholesterol test.