A protein called XPG plays a previously unknown and critical role helping to maintain genome stability in human cells. It may also help prevent breast, ovarian, and other cancers associated with defective BRCA genes.
Berkeley Lab researchers have developed the first clinically-relevant mouse model of human breast cancer to successfully express functional estrogen receptor positive adenocarcinomas.
This model should be a powerful tool for testing therapies for aggressive ER+ breast cancers and for studying luminal cancers — the most prevalent and deadliest forms of breast cancer.
Berkeley Lab researchers have developed a new family of nanocarriers, called “3HM,” that meets all the size and stability requirements for effectively delivering therapeutic drugs to the brain for the treatment of a deadly form of cancer known as glioblastoma multiforme.
Berkeley Lab researchers have been awarded $1.3 million for two sets of studies to better understand the health impacts of thirdhand smoke, the noxious residue that clings to virtually all indoor surfaces long after the secondhand smoke from a cigarette has cleared out.
Time-lapse imaging can make complicated processes easier to grasp. Berkeley Lab scientists are using a similar approach to study how cells repair DNA damage. Microscopy images are acquired about every thirty minutes over a span of up to two days, and the resulting sequence of images shows ever-changing hotspots inside cells where DNA is under repair.
Berkeley Lab scientists are developing a cell culture that could help researchers better identify chemicals that increase breast cancer susceptibility. The scientists will grow the culture using adult stem cells obtained from breast tissue. Their test will show if a chemical causes a breakdown in cell-to-cell communication, which is a fundamental defect of cancer.
Berkeley Lab scientists studied mice and found their risk of mammary cancer from low-dose radiation depends a great deal on their genetic makeup. They also learned key details about how genes and the cells immediately surrounding a tumor (also called the tumor microenvironment) affect cancer risk.
Berkeley Lab researchers have won two grants from the DOE and NCI that focus on particle beam-based therapies for treating cancer as well as on building faster, more powerful lasers for accelerators.
Berkeley Lab scientists have learned new details about how an important tumor-suppressing protein, called p53, binds to the human genome. As with many things in life, they found that context makes a big difference.
Berkeley Lab scientists have developed a new method that can easily create immortal human mammary epithelial cells. The cells could greatly facilitate the examination of cell immortalization as it actually occurs during cancer progression.