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Berkeley Lab Wins Three 2014 R&D 100 Awards

Berkeley Lab has won three 2014 R&D 100 awards. This year’s winners include a fast way to analyze the chemical composition of cells, a suite of genetic tools to improve crops, and a method to screen images of 3-D cell cultures for cancer cells. The technologies could lead to advances in biofuels, food crops, drug development, and biomaterials, and a to better understanding of microbial communities, to name a few potential benefits.

New Clues to Why Older Women are More Vulnerable to Breast Cancer

Berkeley Lab scientists have gained more insights into why older women are more susceptible to breast cancer. They found that as women age, the cells responsible for maintaining healthy breast tissue stop responding to their immediate surroundings, including mechanical cues that should prompt them to suppress nearby tumors.

New Details on Microtubules and How the Anti-Cancer Drug Taxol Works

Berkeley Lab researchers have produced images of microtubule assembly and disassembly at the unprecedented resolution of 5 angstroms, providing new insight into the success of the anti-cancer drug Taxol and pointing the way to possible improvements.

Vast Gene-Expression Map Yields Neurological and Environmental Stress Insights

A consortium led by Berkeley Lab scientists has conducted the largest survey yet of how information encoded in an animal genome is processed in different organs, stages of development, and environmental conditions. Their findings, based on fruit fly research, paint a new picture of how genes function in the nervous system and in response to environmental stress.

Berkeley Lab Startup Wants to Know How Damaged Your DNA Is

Berkeley Lab scientist Sylvain Costes has come up with a way to automate the job of screening for DNA damage, using a proprietary algorithm and a machine to scan specimens and objectively score the damaged DNA. Now he has launched Exogen Biotechnology to commercialize the technology and, he hopes, make tests for DNA damage as common as a cholesterol test.

How a Shape-shifting DNA-repair Machine Fights Cancer

Maybe you’ve seen the movies or played with toy Transformers, those shape-shifting machines that morph in response to whatever challenge they face. It turns out that DNA-repair machines in your cells use a similar approach to fight cancer and other diseases, according to new research led by Berkeley Lab scientists.

A Role of Sugar Uptake in Breast Cancer Revealed

Berkeley Lab researchers have shown that aerobic glycolysis – glucose metabolism in the presence of oxygen – is not the consequence of the cancerous activity of malignant cells, as has been widely believed, but is itself a cancerous event.

Radiotherapy in Girls and the Risk of Breast Cancer Later in Life

Berkeley Lab researchers have helped determine why exposing young women and girls under the age of 20 to ionizing radiation can substantially raise the risk of their developing breast cancer later in life.

Tiny Bubbles Hold Big Promise for NMR/MRI

Tiny bubbles carrying hyperpolarized xenon gas hold big promise for greatly increasing the sensitivity of NMR/MRI technologies.

Cancerous Traffic Jams: Biomechanical Factor in Malignancies Identified

Berkeley Lab researchers have demonstrated that the malignant activity of a cellular protein system strongly linked to breast cancer can arise from what essentially are protein traffic jams.