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Posts Tagged ‘medical’

Berkeley Lab Researchers Discover How and Where Breast Tumor Cells Become Dormant and What Causes Them to Become Metastatic

June 3, 2013

Berkeley Lab researchers have identified the microenvironment surrounding microvasculature as a niche where dormant breast cancer cells may reside, and the sprouting of microvasculature blood vessels as the event that transforms dormant cancer cells into metastatic tumors.

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Copper on the Brain

May 24, 2013

Berkeley Lab researchers have developed unique fluorescent probes for molecular imaging of copper in the brain, and are using these probes to uncover new information critical to a healthy mind.

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Berkeley Lab Researchers Find New Clue to Clinical Trial Failures of MMP Cancer Therapies

February 11, 2013

Failure of Highly Touted MMP Cancer Therapies May Be Explained

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New Details on the Molecular Machinery of Cancer

February 11, 2013

New details into the activation of a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies have been reported by Berkeley Lab researchers.

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Genome-wide Atlas of Gene Enhancers in the Brain On-line

January 31, 2013

Berkeley Lab researchers have unveiled a first-of-its-kind atlas of gene-enhancers in the brain that should greatly benefit future research into the underlying causes of neurological disorders such as autism, epilepsy and schizophrenia.

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Berkeley Lab Scientists Create First 3-D Model of a Protein Critical to Embryo Development

September 14, 2012

Berkeley Lab researchers have constructed the first detailed and complete picture of a protein complex that is tied to human birth defects as well as the progression of many forms of cancer. Knowing the architecture of this protein, PRC2, should be a boon to its future use in the development of new and improved therapeutic drugs.

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Protein Linked to Therapy Resistance in Breast Cancer

September 11, 2012

Berkeley Lab researchers have identified the FAM83A protein as a possible new oncogene and linked it to therapy resistance in breast cancer. This discovery helps explain the clinical correlation between a high expression of FAM83A and a poor prognosis for breast cancer patients, and may also provide a new target for future therapies.

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Exciting New Field of Bioorthogonal Chemistry Owes a Debt to Curiosity-Driven Research from Previous Eras

April 9, 2012

In her Kavli Lecture at the American Chemical Society’s spring meeting, Carolyn Bertozzi described how her ground-breaking bioorthogonal chemistry research made use of experiments nearly a century ago by two German chemists whose work rose from scientific curiosity.

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Responding to the Radiation Threat

March 6, 2012

Berkeley Lab Researchers are developing a promising treatment for safely decontaminating humans exposed to radioactive actinides from a major radiation exposure event, such as a nuclear reactor accident or a “dirty bomb” terrorist attack. The treatment, which can be administered as a pill that can result in the excretion of approximately 90-percent of the actinide contaminants within 24 hours, has been advanced through the initial pre-clinical phases.

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How Good Cholesterol Turns Bad

February 21, 2012

Berkeley Lab researchers have found new evidence to explain how cholesteryl ester transfer protein (CETP) mediates the transfer of cholesterol from “good” high density lipoproteins (HDLs) to “bad” low density lipoproteins (LDLs). These findings point the way to the design of safer, more effective next generation CETP inhibitors that could help prevent the development of heart disease.

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