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Posts Tagged ‘synthetic biology’

Berkeley Lab’s Adam Arkin Wins 2013 Lawrence Award

April 16, 2014

Adam Arkin, director of Berkeley Lab’s Physical Biosciences Division, has been named one of six recipients of the 2013 Ernest Orlando Lawrence Award by U.S. Energy Secretary Ernest Moniz.

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What About BOB?

April 7, 2014

The Berkeley Open Biofoundry – BOB – is a Berkeley Lab proposal to DARPA aimed at providing the science and technology that will enable the engineering of biological systems to produce valuable chemical products on a commercial scale.

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Resistance is Not Futile: Joint BioEnergy Institute Researchers Engineer Resistance to Ionic Liquids in Biofuel Microbes

March 26, 2014

Researchers with the Joint BioEnergy Institute (JBEI) have identified the genetic origins of a microbial resistance to ionic liquids and successfully introduced this resistance into a strain of E. coli bacteria for the production of advanced biofuels.

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New Technique for Identifying Gene-Enhancers

March 24, 2014

Berkeley Lab researchers led the development of a new technique for identifying gene enhancers – sequences of DNA that act to amplify the expression of a specific gene – in the genomes of humans and other mammals. Called SIF-seq, this new technique complements existing genomic tools, such as ChIP-seq, and offers additional benefits.

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New Insight into an Emerging Genome-Editing Tool

February 6, 2014

A collaboration led by Berkeley Lab’s Jennifer Doudna and Eva Nogales has produced the first detailed look at the 3D structure of the Cas9 enzyme and how it partners with guide RNA to interact with target DNA. The results should enhance Cas9’s value and versatility as a genome-editing tool.

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Puzzling Question in Bacterial Immune System Answered

January 29, 2014

Berkeley researchers have answered a central question about Cas9, an enzyme that plays an essential role in the bacterial immune system and is fast becoming a valuable tool for genetic engineering: How is Cas9 able to precisely discriminate between non-self DNA that must be degraded and self DNA that may be almost identical within genomes that are millions to billions of base pairs long.

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Less Toxic Metabolites, More Chemical Product

October 29, 2013

By preventing the build-up of toxic metabolites in engineered microbes, a dynamic regulatory system developed at JBEI can help boost production of an advanced biofuel, a therapeutic drug, or other valuable chemical products. The system has already been used to double the production in E. coli of amorphadiene, a precursor to the premier antimalarial drug artemisinin.

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Expressly Unfit for the Laboratory

June 19, 2013

A new Berkeley Lab study challenges the orthodoxy of microbiology, which holds that in response to environmental changes, bacterial genes will boost production of needed proteins and decrease production of those that aren’t. The study found that for bacteria in the laboratory there was little evidence of adaptive genetic response.

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Making Do with More: Joint BioEnergy Institute Researchers Engineer Plant Cell Walls to Boost Sugar Yields for Biofuels

March 29, 2013

Using the tools of synthetic biology, JBEI researchers are engineering healthy plants whose lignocellulosic biomass can more easily be broken down into simple sugars for the production of clean, green and renewable advanced biofuels.

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Predictability: The Brass Ring For Synthetic Biology

March 13, 2013

DNA sequences and statistical models have been unveiled that greatly increase the reliability and precision by which microbes can be engineered.

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