Berkeley Lab scientists have discovered the details of an unconventional coupling between a bacterial protein and a mineral that allows the bacterium to breathe when oxygen is not available.
A new algorithmic framework called M-TIP helps researchers determine the molecular structure of proteins and viruses from X-ray free electron laser data, which is crucial in fields like biology and medicine.
It turns out your skin is crawling with single-celled microorganisms – and they’re not just bacteria. A study by Lawrence Berkeley National Laboratory and the Medical University of Graz has found that the skin microbiome also contains archaea, a type of extreme-loving microbe, and that the amount of it varies with age.
Scientists at Berkeley Lab and Michigan State University are providing the clearest view yet of an intact bacterial microcompartment, revealing at atomic-level resolution the structure and assembly of the organelle’s protein shell. This work could benefit research in bioenergy and pathogenesis, and it could lead to new methods of bioengineering bacteria for beneficial purposes.
Cryo-electron microscopy (cryo-EM)—which enables the visualization of viruses, proteins, and other biological structures at the molecular level—is a critical tool used to advance biochemical knowledge. Now Lawrence Berkeley National Laboratory (Berkeley Lab) researchers have extended cryo-EM’s impact further by developing a new computational algorithm that was instrumental in constructing a 3-D atomic-scale model of bacteriophage
A team of scientists at Berkeley Lab has developed an unsupervised multi-scale machine learning technique that can automatically and specifically capture biomedical events or concepts directly from raw data.
Scientists have enlisted the exotic properties of graphene to function like the film of an incredibly sensitive camera system in visually mapping tiny electric fields. They hope to enlist the new method to image electrical signaling networks in our hearts and brains.
Scientists have produced detailed 3-D visualizations that show an unexpected connectivity in the genetic material at the center of cells, providing a new understanding of a cell’s evolving architecture.
Berkeley Lab researchers found that aberrant strands of genetic code have telltale signs that enable gateway proteins to recognize and block them from exiting the nucleus. Their findings shed light on a complex system of cell regulation that acts as a form of quality control for the transport of genetic information. A more complete picture of how genetic information gets expressed in cells is important in disease research.
A new Berkeley Lab-developed electron-beam imaging technique, tested on samples of nanoscale gold and carbon, greatly improves images of light elements. The technique can reveal structural details for materials that would be overlooked by some traditional methods.