A team based at Berkeley Lab’s Advanced Light Source is making waves with its new approach for whole-cell visualization, using the world’s first soft X-ray tomography (SXT) microscope built for biological and biomedical research. In its latest study, published in Science Advances, the team used its platform to reveal never-before-seen details about insulin secretion in pancreatic cells taken from rats.
-Written By Lida Gifford Cyclic proteins that assemble from multiple identical subunits (homo-oligomers) play key roles in many biological processes, including cell signaling and enzymatic catalysis and protein function. Researchers in Berkeley Lab’s Molecular Biophysics and Integrated Bioimaging (MBIB) Division worked with University of Washington’s David Baker, who led a team to design in silico
Berkeley Lab researchers collaborated with colleagues from the University of Indiana and Texas A&M University to solve the atomic structure of a Zika virus protein that is key to viral reproduction. The X-ray studies were conducted at the Advanced Light Source in the Berkeley Center for Structural Biology.
Cryo-electron microscopy (cryo-EM)—which enables the visualization of viruses, proteins, and other biological structures at the molecular level—is a critical tool used to advance biochemical knowledge. Now Lawrence Berkeley National Laboratory (Berkeley Lab) researchers have extended cryo-EM’s impact further by developing a new computational algorithm that was instrumental in constructing a 3-D atomic-scale model of bacteriophage
X-ray studies of meteorite samples, conducted by NASA and Berkeley Lab researchers, could help gauge threats to Earth by providing new insights on the microscopic makeup of asteroids and how they break up in the atmosphere.
X-ray-based experiments at Berkeley Lab will simulate—in microscopic detail—spacecraft parachute fabric performance in the extreme conditions of other planets’ atmospheres.
NASA is developing a new family of flexible heat-shield systems with a woven carbon-fiber base material, and is using X-rays at Berkeley Lab’s Advanced Light Source to test the designs.
NASA and Berkeley Lab researchers have teamed up to explore next-generation spacecraft materials at the microscale using an X-ray technique that produces 3-D images. This work could help ensure future spacecraft survive the rigors of otherworldly atmospheres.
Visiting scientists gave input during a workshop last week on the range of new X-ray science made possible by a planned upgrade of the Advanced Light Source.
Defects and jagged surfaces at the edges of nanosized platinum and gold particles are key hot spots for chemical reactivity, researchers confirmed using a unique infrared probe.