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Epic Research Endeavor Reveals Cause of Deadly Digestive Disease in Children

Nearly ten years ago, a group of Israeli clinical researchers emailed Berkeley Lab geneticist Len Pennacchio to ask for his team’s help in solving the mystery of a rare inherited disease that caused extreme, and sometimes fatal, chronic diarrhea in children. Now, following an arduous investigative odyssey that expanded our understanding of regulatory sequences in the human genome, the multinational scientific group has announced the discovery of the genetic explanation for this disease.

Unique Synthetic Antibodies Show Promise for Improved Disease and Toxin Detection

Scientists have invented a new “synthetic antibody” that could make screening for diseases easier and less expensive than current go-to methods. Writing in the journal Nano Letters, a team led by Markita Landry of Berkeley Lab and UC Berkeley describes how peptoids – synthetically produced molecules, first created by Ron Zuckermann at Berkeley Lab’s Molecular Foundry, that

Mouse Study Yields Long-Awaited Insights into Human Stomach Cancer

Mice have been instrumental in the study of cancer, but like all animal models of human diseases, they have their limitations. For stomach cancer in particular, mice have historically been regarded as quite poor research organisms because rodents rarely develop spontaneous stomach tumors. But results from a new study are about to shake up the paradigm.