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Cancerous Traffic Jams: Biomechanical Factor in Malignancies Identified

Berkeley Lab researchers have demonstrated that the malignant activity of a cellular protein system strongly linked to breast cancer can arise from what essentially are protein traffic jams.

Berkeley Lab Confirms Thirdhand Smoke Causes DNA Damage

A study led by researchers from Lawrence Berkeley National Laboratory has found for the first time that thirdhand smoke—the noxious residue that clings to virtually all surfaces long after the secondhand smoke from a cigarette has cleared out—causes significant genetic damage in human cells.

Berkeley Lab Researchers Discover How and Where Breast Tumor Cells Become Dormant and What Causes Them to Become Metastatic

Berkeley Lab researchers have identified the microenvironment surrounding microvasculature as a niche where dormant breast cancer cells may reside, and the sprouting of microvasculature blood vessels as the event that transforms dormant cancer cells into metastatic tumors.

Berkeley Lab Discoveries Open New Hope for MMP Cancer Therapies

New evidence supports earlier findings that cancer therapy drugs based on a family of enzymes called metalloproteinases (MMPs) failed in clinical trials because they were aimed at the wrong target.

Berkeley Lab Researchers Find New Clue to Clinical Trial Failures of MMP Cancer Therapies

Failure of Highly Touted MMP Cancer Therapies May Be Explained

New Details on the Molecular Machinery of Cancer

New details into the activation of a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies have been reported by Berkeley Lab researchers.

Protein Linked to Therapy Resistance in Breast Cancer

Berkeley Lab researchers have identified the FAM83A protein as a possible new oncogene and linked it to therapy resistance in breast cancer. This discovery helps explain the clinical correlation between a high expression of FAM83A and a poor prognosis for breast cancer patients, and may also provide a new target for future therapies.

Aging and Breast Cancer

A big step towards understanding the cellular basis for why women over the age of 50 are much more vulnerable to breast cancer has been taken by Berkeley Lab researchers. They determined that aging causes an increase in a type of adult stem cell believed to be at the root of many breast cancers, and a decrease in cells believed to serve as tumor suppressors.

New Findings in Breast Cancer

A Berkeley Lab-University of Copenhagen collaboration found that luminal-like breast cancer cells with no detectable stem cell qualities can generate larger tumors than their basal-like counterparts. This contradicts prevailing beliefs and could impact future breast cancer diagnosis and treatment.

Berkeley Lab Researchers Discover a Rotational Motion of Cells that Plays a Critical Role in Their Normal Development

Berkeley Lab researchers have discovered a rotational motion that plays a critical role in the ability of breast cells to form the spherical structures in the mammary gland known as acini. This rotation, called “CAMo,” for coherent angular motion, is necessary for the cells to form spheres. Otherwise, cells undergo random motion, leading to loss of structure and malignancy.