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3D Dynamic Imaging of Soft Materials

Through a combination of transmission electron microscopy (TEM) and a unique graphene liquid cell, Berkeley Lab researchers have recorded the three-dimensional motion of DNA connected to gold nanocrystals, the first reported use of TEM for 3D dynamic imaging of soft materials.

Atom by Atom, Bond by Bond, a Chemical Reaction Caught in the Act

Berkeley Lab scientists have produced remarkable images of carbon atoms and the bonds among them. Resembling glowing textbook diagrams, hydrocarbon molecules are shown in high resolution for the first time before and after the breaking, rearrangement of atoms, and reforming of bonds during a complex chemical reaction.

Reading the Human Genome

Berkeley Lab researchers have achieved a major advance in understanding how genetic information is transcribed from DNA to RNA by providing the first step-by-step look at the biomolecular machinery that reads the human genome.

What Kind of Iron is in the Southern Ocean?

The Southern Ocean, circling the Earth between Antarctica and the southernmost regions of Africa, South America, and Australia, is notorious for its High Nutrient, Low Chlorophyl zones, areas otherwise rich in nutrients but poor in essential iron. Sea life is less abundant in these regions because the growth of phytoplankton, the marine plants that form

First Direct Observation of Oriented Attachment in Nanocrystal Growth

Berkeley Lab researchers have reported the first direct observation of nanoparticles undergoing oriented attachment, the critical step in biomineralization and the growth of nanocrystals. A better understanding of oriented attachment in nanoparticles is a key to synthesizing new materials with remarkable structural properties.

Nanoparticles Seen as Artificial Atoms

Observing the formation of nanorods in real-time, Berkeley Lab researchers found that nanoparticles become attached to form winding chains that eventually align, attach end-to-end, straighten and stretch into elongated nanowires. This supports the theory of nanoparticles acting like artificial atoms during crystal growth and points the way to future energy devices.

How Good Cholesterol Turns Bad

Berkeley Lab researchers have found new evidence to explain how cholesteryl ester transfer protein (CETP) mediates the transfer of cholesterol from “good” high density lipoproteins (HDLs) to “bad” low density lipoproteins (LDLs). These findings point the way to the design of safer, more effective next generation CETP inhibitors that could help prevent the development of heart disease.

A Single Cell Endoscope

Berkeley Lab researchers have developed a nanowire endoscope that can provide high-resolution optical images of the interior of a single living cell, or precisely deliver genes, proteins, therapeutic drugs or other cargo without injuring or damaging the cell.

Partnership for Progress in Electronics Strengthened by New Lab-Industry Investment

Through the Center for X-Ray Optics, Berkeley Lab and leading semiconductor manufacturers have mutually invested in major new facilities at the Advanced Light Source for advanced extreme-ultraviolet lithography, including clean rooms, wafer processing facilities, and microlithography test tools too costly for individual manufacturers.

A SHARP New Microscope for the Next Generation of Microchips

Scientists at Berkeley Lab’s Advanced Light Source and Center for X-Ray Optics are working with colleagues at leading semiconductor manufacturers to build SHARP, the world’s most advanced extreme-ultraviolet-light microscope, to study and design the photolithography masks, materials, patterns, and mask architectures essential to producing the next generation of integrated circuits.