A superfast detector installed on an electron microscope at Berkeley Lab’s Molecular Foundry will reveal atomic-scale details across a larger sample area than could be seen before, and produce movies showing chemistry in action and changes in materials.
Experiments conducted at Berkeley Lab helped to confirm that samples of interplanetary particles – collected from Earth’s upper atmosphere and believed to originate from comets – contain dust leftover from the initial formation of the solar system.
Researchers at the Berkeley Lab now have access to a unique new microscope that combines atomic-scale imaging capabilities with the ability to observe real-world sample properties and behavior in real time.
Researchers at Lawrence Berkeley National Laboratory and UC Berkeley have combined cutting-edge cryo-electron microscopy (cryo-EM) with computational molecular modeling to produce a near atomic-resolution model of the interaction between microtubules – crucial components of eukaryotic cell ultrastructure – and microtubule-associated proteins called tau.
Lab scientists use cryo-electron microscopy to gain a deeper understanding of the structure of a regulatory complex. Their research could open up new possibilities for cancer therapies.
Biologists at Berkeley Lab and UC Berkeley used cryo-EM to resolve the structure of a ring of proteins used by the immune system to summon support when under attack, providing new insight into potential strategies for protection from pathogens. The researchers captured the high-resolution image of a protein ring, called an inflammasome, as it was bound to flagellin, a protein from the whiplike tail used by bacteria to propel themselves forward.
Berkeley Lab played a key role in the 2017 Nobel Prize in chemistry, awarded today, honoring the development of cryo-EM, an imaging technique that has launched the fields of structural biology and biochemistry into an exciting new era of discovery.
Using cryo-electron microscopy (cryo-EM), Berkeley Lab scientists have obtained 3-D models of a human transcription factor at near-atomic resolutions. The protein complex is critical to gene expression and DNA repair, and could aid research in targeted drug development.
Combining speed with incredible precision, a team of researchers has developed a way to print a nanoscale imaging probe onto the tip of a glass fiber as thin as a human hair, accelerating the production of the promising new device from several per month to several per day.
A multi-institutional team of researchers, including scientists from Berkeley Lab, have used a new scanning electron microscopy technique to resolve the unique atomic structure at the surface of a material. This new technique holds promise for the study of catalysis, corrosion and other critical chemical reactions.