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Detailed View of Immune Proteins Could Lead to New Pathogen-Defense Strategies

Biologists at Berkeley Lab and UC Berkeley used cryo-EM to resolve the structure of a ring of proteins used by the immune system to summon support when under attack, providing new insight into potential strategies for protection from pathogens. The researchers captured the high-resolution image of a protein ring, called an inflammasome, as it was bound to flagellin, a protein from the whiplike tail used by bacteria to propel themselves forward.

Berkeley Lab Tech Brings Nobel-Winning Cryo-EM Into Sharper Focus

Berkeley Lab played a key role in the 2017 Nobel Prize in chemistry, awarded today, honoring the development of cryo-EM, an imaging technique that has launched the fields of structural biology and biochemistry into an exciting new era of discovery.

Berkeley Lab Scientists Map Key DNA Protein Complex at Near-Atomic Resolution

Using cryo-electron microscopy (cryo-EM), Berkeley Lab scientists have obtained 3-D models of a human transcription factor at near-atomic resolutions. The protein complex is critical to gene expression and DNA repair, and could aid research in targeted drug development.

Scientists Print Nanoscale Imaging Probe onto Tip of Optical Fiber

Combining speed with incredible precision, a team of researchers has developed a way to print a nanoscale imaging probe onto the tip of a glass fiber as thin as a human hair, accelerating the production of the promising new device from several per month to several per day.

A New Look at Surface Chemistry

A multi-institutional team of researchers, including scientists from Berkeley Lab, have used a new scanning electron microscopy technique to resolve the unique atomic structure at the surface of a material. This new technique holds promise for the study of catalysis, corrosion and other critical chemical reactions.

Berkeley Lab Develops Nanoscope to Probe Chemistry on the Molecular Scale

By combining atomic force microscopy with infrared synchrotron light, researchers from Berkeley Lab’s Advanced Light Source and the University of Colorado have improved the spatial resolution of infrared spectroscopy by orders of magnitude, while simultaneously covering its full spectroscopic range, enabling the investigation of variety of nanoscale, mesoscale, and surface phenomena that were previously difficult to study.

3D Dynamic Imaging of Soft Materials

Through a combination of transmission electron microscopy (TEM) and a unique graphene liquid cell, Berkeley Lab researchers have recorded the three-dimensional motion of DNA connected to gold nanocrystals, the first reported use of TEM for 3D dynamic imaging of soft materials.

Atom by Atom, Bond by Bond, a Chemical Reaction Caught in the Act

Berkeley Lab scientists have produced remarkable images of carbon atoms and the bonds among them. Resembling glowing textbook diagrams, hydrocarbon molecules are shown in high resolution for the first time before and after the breaking, rearrangement of atoms, and reforming of bonds during a complex chemical reaction.

Reading the Human Genome

Berkeley Lab researchers have achieved a major advance in understanding how genetic information is transcribed from DNA to RNA by providing the first step-by-step look at the biomolecular machinery that reads the human genome.

What Kind of Iron is in the Southern Ocean?

The Southern Ocean, circling the Earth between Antarctica and the southernmost regions of Africa, South America, and Australia, is notorious for its High Nutrient, Low Chlorophyl zones, areas otherwise rich in nutrients but poor in essential iron. Sea life is less abundant in these regions because the growth of phytoplankton, the marine plants that form