A synthetic biology project begun 13 years ago by Jay Keasling was culminated with the announcement that a microbial-based version of the antimalarial drug artemisinin has been shipped to African nations where it is most needed.
JBEI researchers have developed a powerful new tool that can help advance the genetic engineering of “fuel” crops for clean, green and renewable bioenergy – an assay that enables scientists to identify and characterize the function of nucleotide sugar transporters, critical components in the biosynthesis of plant cell walls.
The JBEI GT Collection, the first glycosyltransferase clone collection specifically targeted for the study of plant cell wall biosynthesis, is expected to drive basic scientific understanding of GTs and better enable the manipulation of plant cell walls for the production of biofuels and other chemical products.
The Berkeley Open Biofoundry – BOB – is a Berkeley Lab proposal to DARPA aimed at providing the science and technology that will enable the engineering of biological systems to produce valuable chemical products on a commercial scale.
Researchers with the Joint BioEnergy Institute (JBEI) have identified the genetic origins of a microbial resistance to ionic liquids and successfully introduced this resistance into a strain of E. coli bacteria for the production of advanced biofuels.
Researchers at the Joint BioEnergy Institute (JBEI) have identified a rain forest microbe that feasts on the lignin in plant leaf litter, making it a potential ally for the cost-effective production of advanced biofuels.
By preventing the build-up of toxic metabolites in engineered microbes, a dynamic regulatory system developed at JBEI can help boost production of an advanced biofuel, a therapeutic drug, or other valuable chemical products. The system has already been used to double the production in E. coli of amorphadiene, a precursor to the premier antimalarial drug artemisinin.
JBEI researchers are developing wiki-based technoeconomic models to help accelerate the development of next generation biofuels that are economically competitive with petroleum-based fuels.
Joint BioEnergy Institute (JBEI) researchers save water and reduce pollution with the first one-pot, wash-free, process for the ionic liquid pretreatment and saccharification of switchgrass, one of the leading biofuel feedstock candidates.
A multi-institutional collaboration led by researchers with the Joint BioEnergy Institute (JBEI) and Joint Genome Institute (JGI) has developed a promising technique for identifying microbial enzymes that can effectively deconstruct biomass into fuel sugars under refinery processing conditions.