Using cryo-electron microscopy (cryo-EM), Berkeley Lab scientists have obtained 3-D models of a human transcription factor at near-atomic resolutions. The protein complex is critical to gene expression and DNA repair, and could aid research in targeted drug development.
Combining speed with incredible precision, a team of researchers has developed a way to print a nanoscale imaging probe onto the tip of a glass fiber as thin as a human hair, accelerating the production of the promising new device from several per month to several per day.
A multi-institutional team of researchers, including scientists from Berkeley Lab, have used a new scanning electron microscopy technique to resolve the unique atomic structure at the surface of a material. This new technique holds promise for the study of catalysis, corrosion and other critical chemical reactions.
By combining atomic force microscopy with infrared synchrotron light, researchers from Berkeley Lab’s Advanced Light Source and the University of Colorado have improved the spatial resolution of infrared spectroscopy by orders of magnitude, while simultaneously covering its full spectroscopic range, enabling the investigation of variety of nanoscale, mesoscale, and surface phenomena that were previously difficult to study.
Through a combination of transmission electron microscopy (TEM) and a unique graphene liquid cell, Berkeley Lab researchers have recorded the three-dimensional motion of DNA connected to gold nanocrystals, the first reported use of TEM for 3D dynamic imaging of soft materials.
Berkeley Lab scientists have produced remarkable images of carbon atoms and the bonds among them. Resembling glowing textbook diagrams, hydrocarbon molecules are shown in high resolution for the first time before and after the breaking, rearrangement of atoms, and reforming of bonds during a complex chemical reaction.
Berkeley Lab researchers have achieved a major advance in understanding how genetic information is transcribed from DNA to RNA by providing the first step-by-step look at the biomolecular machinery that reads the human genome.
The Southern Ocean, circling the Earth between Antarctica and the southernmost regions of Africa, South America, and Australia, is notorious for its High Nutrient, Low Chlorophyl zones, areas otherwise rich in nutrients but poor in essential iron. Sea life is less abundant in these regions because the growth of phytoplankton, the marine plants that form
Berkeley Lab researchers have reported the first direct observation of nanoparticles undergoing oriented attachment, the critical step in biomineralization and the growth of nanocrystals. A better understanding of oriented attachment in nanoparticles is a key to synthesizing new materials with remarkable structural properties.
Observing the formation of nanorods in real-time, Berkeley Lab researchers found that nanoparticles become attached to form winding chains that eventually align, attach end-to-end, straighten and stretch into elongated nanowires. This supports the theory of nanoparticles acting like artificial atoms during crystal growth and points the way to future energy devices.