By combining atomic force microscopy with infrared synchrotron light, researchers from Berkeley Lab’s Advanced Light Source and the University of Colorado have improved the spatial resolution of infrared spectroscopy by orders of magnitude, while simultaneously covering its full spectroscopic range, enabling the investigation of variety of nanoscale, mesoscale, and surface phenomena that were previously difficult to study.
Through a combination of transmission electron microscopy (TEM) and a unique graphene liquid cell, Berkeley Lab researchers have recorded the three-dimensional motion of DNA connected to gold nanocrystals, the first reported use of TEM for 3D dynamic imaging of soft materials.
Berkeley Lab scientists have produced remarkable images of carbon atoms and the bonds among them. Resembling glowing textbook diagrams, hydrocarbon molecules are shown in high resolution for the first time before and after the breaking, rearrangement of atoms, and reforming of bonds during a complex chemical reaction.
Berkeley Lab researchers have achieved a major advance in understanding how genetic information is transcribed from DNA to RNA by providing the first step-by-step look at the biomolecular machinery that reads the human genome.
The Southern Ocean, circling the Earth between Antarctica and the southernmost regions of Africa, South America, and Australia, is notorious for its High Nutrient, Low Chlorophyl zones, areas otherwise rich in nutrients but poor in essential iron. Sea life is less abundant in these regions because the growth of phytoplankton, the marine plants that form
Berkeley Lab researchers have reported the first direct observation of nanoparticles undergoing oriented attachment, the critical step in biomineralization and the growth of nanocrystals. A better understanding of oriented attachment in nanoparticles is a key to synthesizing new materials with remarkable structural properties.
Observing the formation of nanorods in real-time, Berkeley Lab researchers found that nanoparticles become attached to form winding chains that eventually align, attach end-to-end, straighten and stretch into elongated nanowires. This supports the theory of nanoparticles acting like artificial atoms during crystal growth and points the way to future energy devices.
Berkeley Lab researchers have found new evidence to explain how cholesteryl ester transfer protein (CETP) mediates the transfer of cholesterol from “good” high density lipoproteins (HDLs) to “bad” low density lipoproteins (LDLs). These findings point the way to the design of safer, more effective next generation CETP inhibitors that could help prevent the development of heart disease.
Berkeley Lab researchers have developed a nanowire endoscope that can provide high-resolution optical images of the interior of a single living cell, or precisely deliver genes, proteins, therapeutic drugs or other cargo without injuring or damaging the cell.
Through the Center for X-Ray Optics, Berkeley Lab and leading semiconductor manufacturers have mutually invested in major new facilities at the Advanced Light Source for advanced extreme-ultraviolet lithography, including clean rooms, wafer processing facilities, and microlithography test tools too costly for individual manufacturers.