As the name implies, crystallography requires crystals – specifically, purified samples of the molecule of interest, coaxed into a crystal form. But most molecules form powders composed of jumbled granules, not picture-ready crystals. A new computer algorithm, combined with a state-of-the-art laser, can adapt X-ray crystallography for the many not-so-neat-and-tidy compounds that scientists seek to study.
This video shows steps of the enzymatic reaction that makes a double-ringed molecule, which is the structural starting point to produce molecules in a large class of antibiotics. (Credit: Patrick Rabe/Oxford University) Scientists who specialize in studying the atom-by-atom choreography of enzymes have revealed new insights into the function of isopenicillin N synthase, an
By Ashleigh Papp “The dream of predicting a protein shape just from its gene sequence is now a reality,” said Paul Adams, Associate Laboratory Director for Biosciences at Berkeley Lab. For Adams and other structural biologists who study proteins, predicting their shape offers a key to understanding their function and accelerating treatments for diseases like
Scientists from three national labs have published a comprehensive study that – alongside other recent, complementary studies of coronavirus proteins and genetics – represents the first step toward developing treatments for COVID-19.
Berkeley Lab scientist who leads the development of a widely used data analysis software discusses the role of structural biology in vaccine and antiviral research.
A team of biologists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells. The structural map – which is now published in the journal PNAS, but has been open-access for the scientific community since August – has laid the groundwork for new antiviral treatments and enabled further investigations into how the newly emerged virus ravages the human body.
Blurry photo? There’s a photoshop tool for that. Blurry molecular structure map? Now, there’s a tool for that too.
The discovery of a primitive form of a photosynthetic enzyme will help scientists understand how carbon-fixing organisms oxygenated the atmosphere and how modern plants evolved