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Enzyme Action Movie Shows How Nature Makes Penicillins

This video shows steps of the enzymatic reaction that makes a double-ringed molecule, which is the structural starting point to produce molecules in a large class of antibiotics. (Credit: Patrick Rabe/Oxford University)   Scientists who specialize in studying the atom-by-atom choreography of enzymes have revealed new insights into the function of isopenicillin N synthase, an

AI-Fueled Software Reveals Accurate Protein Structure Prediction

By Ashleigh Papp “The dream of predicting a protein shape just from its gene sequence is now a reality,” said Paul Adams, Associate Laboratory Director for Biosciences at Berkeley Lab. For Adams and other structural biologists who study proteins, predicting their shape offers a key to understanding their function and accelerating treatments for diseases like

Deconstructing the Infectious Machinery of the SARS-CoV-2 Virus

Scientists from three national labs have published a comprehensive study that – alongside other recent, complementary studies of coronavirus proteins and genetics – represents the first step toward developing treatments for COVID-19.

Scientist Q&A: The Molecular Imaging Behind COVID-19 Breakthroughs

Berkeley Lab scientist who leads the development of a widely used data analysis software discusses the role of structural biology in vaccine and antiviral research.

The Odd Structure of ORF8: Scientists Map the Coronavirus Protein Linked to Immune Evasion and Disease Severity

A team of biologists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells. The structural map – which is now published in the journal PNAS, but has been open-access for the scientific community since August – has laid the groundwork for new antiviral treatments and enabled further investigations into how the newly emerged virus ravages the human body.

New Algorithm Sharpens Focus of World’s Most Powerful Microscopes

Blurry photo? There’s a photoshop tool for that. Blurry molecular structure map? Now, there’s a tool for that too.

Study Finds ‘Missing Link’ in the Evolutionary History of Carbon-Fixing Protein Rubisco

The discovery of a primitive form of a photosynthetic enzyme will help scientists understand how carbon-fixing organisms oxygenated the atmosphere and how modern plants evolved