Cryo-electron microscopy (cryo-EM)—which enables the visualization of viruses, proteins, and other biological structures at the molecular level—is a critical tool used to advance biochemical knowledge. Now Lawrence Berkeley National Laboratory (Berkeley Lab) researchers have extended cryo-EM’s impact further by developing a new computational algorithm that was instrumental in constructing a 3-D atomic-scale model of bacteriophage
A team of scientists at Berkeley Lab has developed an unsupervised multi-scale machine learning technique that can automatically and specifically capture biomedical events or concepts directly from raw data.
Scientists have enlisted the exotic properties of graphene to function like the film of an incredibly sensitive camera system in visually mapping tiny electric fields. They hope to enlist the new method to image electrical signaling networks in our hearts and brains.
Scientists have produced detailed 3-D visualizations that show an unexpected connectivity in the genetic material at the center of cells, providing a new understanding of a cell’s evolving architecture.
Berkeley Lab researchers found that aberrant strands of genetic code have telltale signs that enable gateway proteins to recognize and block them from exiting the nucleus. Their findings shed light on a complex system of cell regulation that acts as a form of quality control for the transport of genetic information. A more complete picture of how genetic information gets expressed in cells is important in disease research.
A new Berkeley Lab-developed electron-beam imaging technique, tested on samples of nanoscale gold and carbon, greatly improves images of light elements. The technique can reveal structural details for materials that would be overlooked by some traditional methods.
Scientists have for the first time reengineered a building block of a geometric nanocompartment that occurs naturally in bacteria. The new design provides an entirely new functionality that greatly expands the potential for these compartments to serve as custom-made chemical factories.
Berkeley Lab researchers have developed the first clinically-relevant mouse model of human breast cancer to successfully express functional estrogen receptor positive adenocarcinomas.
This model should be a powerful tool for testing therapies for aggressive ER+ breast cancers and for studying luminal cancers — the most prevalent and deadliest forms of breast cancer.
Berkeley Lab researchers have developed a new family of nanocarriers, called “3HM,” that meets all the size and stability requirements for effectively delivering therapeutic drugs to the brain for the treatment of a deadly form of cancer known as glioblastoma multiforme.
It’s no secret that extremophiles, or microbes that live in places like polar glaciers and toxic waste pools, may hold treasures worth billions. Now basic biology research has led to the formation of CinderBio, a startup co-founded by Berkeley Lab scientists Steve Yannone and Jill Fuss that produces heat- and acid-stable enzymes.