A revolutionary X-ray analytical technique enables researchers at a glance to identify structural similarities and differences between multiple proteins under a variety of conditions and has already been used to gain valuable new insight into a prime protein target for cancer chemotherapy.

Berkeley Lab scientists have developed a computer model of a protein that helps cells interact with their surroundings. Like its biological counterpart, the virtual integrin snippet is about twenty nanometers long. It also responds to changes in energy and other stimuli just as integrins do in real life. The result is a new way to explore how the protein connects a cell’s inner and outer environments.

DNA sequences and statistical models have been unveiled that greatly increase the reliability and precision by which microbes can be engineered.

Berkeley Lab researchers have achieved a major advance in understanding how genetic information is transcribed from DNA to RNA by providing the first step-by-step look at the biomolecular machinery that reads the human genome.

Artificial photosynthesis and other new technologies based on
metalloenzyme catalysis will benefit from a technique for simultaneously collecting both diffraction and spectroscopy data demonstrated by Berkeley Lab and SLAC researchers at the world’s most powerful X-ray laser.

Cilia are critical to good health and a newly discovered cilia partitioning system might be the key

Failure of Highly Touted MMP Cancer Therapies May Be Explained

New details into the activation of a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies have been reported by Berkeley Lab researchers.

Berkeley Lab researchers have unveiled a first-of-its-kind atlas of gene-enhancers in the brain that should greatly benefit future research into the underlying causes of neurological disorders such as autism, epilepsy and schizophrenia.

Berkeley Lab and UC Berkeley researchers have discovered that the transcription factor protein TFIID co-exists in two distinct structural states, a key to genetic expression and TFIID’s ability to initiate the process by which DNA is copied into RNA.