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Posts Tagged ‘biology’

What About BOB?

April 7, 2014

The Berkeley Open Biofoundry – BOB – is a Berkeley Lab proposal to DARPA aimed at providing the science and technology that will enable the engineering of biological systems to produce valuable chemical products on a commercial scale.

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New Technique for Identifying Gene-Enhancers

March 24, 2014

Berkeley Lab researchers led the development of a new technique for identifying gene enhancers – sequences of DNA that act to amplify the expression of a specific gene – in the genomes of humans and other mammals. Called SIF-seq, this new technique complements existing genomic tools, such as ChIP-seq, and offers additional benefits.

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Bright Future for Protein Nanoprobes

March 17, 2014

Berkeley Lab researchers at the Molecular Foundry have discovered surprising new rules for creating ultra-bright light-emitting crystals that are less than 10 nanometers in diameter. These ultra-tiny but ultra-bright nanoprobes should be a big asset for biological imaging, especially deep-tissue optical imaging of neurons in the brain.

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First Look at How Individual Staphylococcus Cells Adhere to Nanostructures Could Lead to New Ways to Thwart Infections

March 4, 2014

A team of researchers led by Berkeley Lab scientists have explored how individual Staphylococcus cells glom onto metallic nanostructures of various shapes and sizes that are not much bigger than the cells themselves. Their work could lead to a more nuanced understanding of what makes a surface less inviting to bacteria.

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New Insight into an Emerging Genome-Editing Tool

February 6, 2014

A collaboration led by Berkeley Lab’s Jennifer Doudna and Eva Nogales has produced the first detailed look at the 3D structure of the Cas9 enzyme and how it partners with guide RNA to interact with target DNA. The results should enhance Cas9’s value and versatility as a genome-editing tool.

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Puzzling Question in Bacterial Immune System Answered

January 29, 2014

Berkeley researchers have answered a central question about Cas9, an enzyme that plays an essential role in the bacterial immune system and is fast becoming a valuable tool for genetic engineering: How is Cas9 able to precisely discriminate between non-self DNA that must be degraded and self DNA that may be almost identical within genomes that are millions to billions of base pairs long.

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A Role of Sugar Uptake in Breast Cancer Revealed

December 18, 2013

Berkeley Lab researchers have shown that aerobic glycolysis – glucose metabolism in the presence of oxygen – is not the consequence of the cancerous activity of malignant cells, as has been widely believed, but is itself a cancerous event.

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What is it About Your Face?

October 24, 2013

Berkeley Lab researchers found thousands of gene enhancers – regulatory sequences of DNA that act to turn-on or amplify the expression of a specific gene – that are involved in the development of the human face. These enhancers help explain why every human face is as unique as a fingerprint.

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3D Dynamic Imaging of Soft Materials

October 2, 2013

Through a combination of transmission electron microscopy (TEM) and a unique graphene liquid cell, Berkeley Lab researchers have recorded the three-dimensional motion of DNA connected to gold nanocrystals, the first reported use of TEM for 3D dynamic imaging of soft materials.

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Radiotherapy in Girls and the Risk of Breast Cancer Later in Life

September 11, 2013

Berkeley Lab researchers have helped determine why exposing young women and girls under the age of 20 to ionizing radiation can substantially raise the risk of their developing breast cancer later in life.

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