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In Pursuit of Perfect Chemistry: A Vision for Unifying Catalysis

Several fields of research have sprung up around the chemical drivers, called catalysts, at work in many industrial processes – including those that boost the production of fuels, fertilizers, and foods – and there is a growing interest in coordinating these research activities to create new, hybrid catalysts with enhanced performance, say researchers at Berkeley Lab and UC Berkeley.

A Game Changer: Metagenomic Clustering Powered by Supercomputers

A team of researchers from the Department of Energy’s Berkeley Lab and Joint Genome Institute took one of the most popular clustering algorithms in modern biology and modified it to run quickly, efficiently and at scale on distributed-memory supercomputers.

X-ray Footprinting Solves Mystery of Metal-Breathing Protein

Berkeley Lab scientists have discovered the details of an unconventional coupling between a bacterial protein and a mineral that allows the bacterium to breathe when oxygen is not available.

New Berkeley Lab Algorithms Extract 3-D Biological Structure From Limited Data

A new algorithmic framework called M-TIP helps researchers determine the molecular structure of proteins and viruses from X-ray free electron laser data, which is crucial in fields like biology and medicine.

What’s On Your Skin? Archaea, That’s What

It turns out your skin is crawling with single-celled microorganisms – and they’re not just bacteria. A study by Lawrence Berkeley National Laboratory and the Medical University of Graz has found that the skin microbiome also contains archaea, a type of extreme-loving microbe, and that the amount of it varies with age.

Study Sheds Light on How Bacterial Organelles Assemble

Scientists at Berkeley Lab and Michigan State University are providing the clearest view yet of an intact bacterial microcompartment, revealing at atomic-level resolution the structure and assembly of the organelle’s protein shell. This work could benefit research in bioenergy and pathogenesis, and it could lead to new methods of bioengineering bacteria for beneficial purposes.

Cryo-Electron Microscopy Achieves Unprecedented Resolution Using New Computational Methods

Cryo-electron microscopy (cryo-EM)—which enables the visualization of viruses, proteins, and other biological structures at the molecular level—is a critical tool used to advance biochemical knowledge. Now Lawrence Berkeley National Laboratory (Berkeley Lab) researchers have extended cryo-EM’s impact further by developing a new computational algorithm that was instrumental in constructing a 3-D atomic-scale model of bacteriophage

New Machine Learning Technique Provides Translational Results

A team of scientists at Berkeley Lab has developed an unsupervised multi-scale machine learning technique that can automatically and specifically capture biomedical events or concepts directly from raw data.

New Graphene-Based System Could Help Us ‘See’ Electrical Signaling in Heart and Nerve Cells

Scientists have enlisted the exotic properties of graphene to function like the film of an incredibly sensitive camera system in visually mapping tiny electric fields. They hope to enlist the new method to image electrical signaling networks in our hearts and brains.

3-D Imaging Technique Maps Migration of DNA-carrying Material at the Center of Cells

Scientists have produced detailed 3-D visualizations that show an unexpected connectivity in the genetic material at the center of cells, providing a new understanding of a cell’s evolving architecture.