Berkeley Lab researchers have developed a 12-gene score tied to the odds of relapse-free breast cancer survival. The scoring system is based upon an analysis of large genomic datasets and patient data, and it could eventually be developed for clinical use.
Berkeley Lab is set to receive $4.6 million over four years as part of an ongoing, federally funded project to create a comprehensive catalog for fundamental genomics research. This latest expansion of the Encyclopedia of DNA Elements (ENCODE) project, or ENCODE 4, is funded by the National Human Genome Research Institute.
Extending the roots of team science at its birthplace, Berkeley Lab will soon bring together researchers from the DOE Joint Genome Institute with those from the Systems Biology Knowledgebase (KBase) under one roof. The groundbreaking for the Integrative Genomics Building (IGB) today celebrates the future colocation of two partnering scientific user community resources and launches construction of the first building in the long-term vision for a consolidated biosciences presence on Berkeley Lab’s main site.
Scientists have produced detailed 3-D visualizations that show an unexpected connectivity in the genetic material at the center of cells, providing a new understanding of a cell’s evolving architecture.
Scientists at Berkeley Lab and UC Berkeley have developed a way to spatially map gene expression data to determine a cell’s fate. The method could go far in interrogating human tissue organization and helping elucidate key aspects of development, human health and disease.
Scientists have captured the first high-resolution 3-D images from individual double-helix DNA segments attached to gold nanoparticles, which could aid in the use of DNA segments as building blocks for molecular devices that function as nanoscale drug-delivery systems, markers for biological research, and components for electronic devices.
A protein called XPG plays a previously unknown and critical role helping to maintain genome stability in human cells. It may also help prevent breast, ovarian, and other cancers associated with defective BRCA genes.
The discovery by Berkeley Lab researchers of the structural basis by which bacteria are able to capture genetic information from viruses and other foreign invaders for use in their own immunological system holds promise for studying or correcting problems in human genomes.
Researchers from Berkeley Lab and the University of Hawaii at Manoa have shown for the first time that cosmic hot spots, such as those near stars, could be excellent environments for the creation of molecular precursors to DNA.
Berkeley Lab researchers have revealed how bacteria “steal” genetic information from foreign invaders for use in their own immunological memory system.