Scientists answered a long-standing question about the role of enhancers. And by better linking the genomic complement of an organism with its expressed characteristics, their work offers new insights that further the growing field of systems biology, which seeks to gain a predictive understanding of living systems.
Researchers at the DOE Joint BioEnergy Institute, in collaboration with the Joint Genome Institute, are reporting the first whole-genome sequence of a mutant population of Kitaake, a model variety of rice. Their high-density, high-resolution catalog of mutations facilitates the discovery of novel genes and functional elements that control diverse biological pathways.
The mechanisms that separate mixtures of oil and water may also help the organization of a part of our DNA called heterochromatin, according to a new Berkeley Lab study. Researchers found that liquid-liquid phase separation helps heterochromatin organize large parts of the genome into specific regions of the nucleus. The work addresses a long-standing question about how DNA functions are organized in space and time, including how genes are silenced or expressed.
Scientists have sequenced the genome of a green alga that has drawn commercial interest as a strong producer of quality lipids for biofuel production. The chromosome-assembly genome of Chromochloris zofingiensis provides a blueprint for new discoveries in producing sustainable biofuels, antioxidants, and other valuable bioproducts.
Scientists have characterized the genome of a freshwater snail that is instrumental in transmitting a parasitic worm to humans. The achievement could help researchers disrupt the life cycle of B. glabrata and potentially eliminate schistosomiasis, also known as snail fever.
Berkeley Lab researchers have developed a 12-gene score tied to the odds of relapse-free breast cancer survival. The scoring system is based on an analysis of large genomic datasets and patient data, and it could eventually be developed for clinical use.
Berkeley Lab is set to receive $4.6 million over four years as part of an ongoing, federally funded project to create a comprehensive catalog for fundamental genomics research. This latest expansion of the Encyclopedia of DNA Elements (ENCODE) project, or ENCODE 4, is funded by the National Human Genome Research Institute.
Extending the roots of team science at its birthplace, Berkeley Lab will soon bring together researchers from the DOE Joint Genome Institute with those from the Systems Biology Knowledgebase (KBase) under one roof. The groundbreaking for the Integrative Genomics Building (IGB) today celebrates the future colocation of two partnering scientific user community resources and launches construction of the first building in the long-term vision for a consolidated biosciences presence on Berkeley Lab’s main site.
Scientists have produced detailed 3-D visualizations that show an unexpected connectivity in the genetic material at the center of cells, providing a new understanding of a cell’s evolving architecture.
Scientists at Berkeley Lab and UC Berkeley have developed a way to spatially map gene expression data to determine a cell’s fate. The method could go far in interrogating human tissue organization and helping elucidate key aspects of development, human health and disease.