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A Matchmaker for Microbiomes

A unique neural network tool is making it possible to accurately infer the interactions between the microbes that are present in a community and the metabolites they produce – a capability that will greatly advance research into the microbiomes in the environment and inside our bodies.

Unlocking the Biochemical Treasure Chest Within Microbes

An international team of scientists led by the Joint Genome Institute has developed a genetic engineering tool that makes producing and analyzing microbial secondary metabolites – the basis for many important agricultural, industrial, and medical products – much easier than before, and could even lead to breakthroughs in biomanufacturing.

A Community-Driven Data Science System to Advance Microbiome Research

The National Microbiome Data Collaborative (NMDC), a new initiative aimed at empowering microbiome research, is gearing up its pilot phase after receiving $10 million of funding from the U.S. Department of Energy Office of Science.

Exploring Human Origins in the Uncharted Territory of Our Chromosomes

A group of geneticists from Berkeley Lab, UC Davis, UC Santa Cruz, and UC Berkeley are unraveling new details about human evolution by studying the uniquely regulated portion of our chromosomes that surround the centromeres.

Epic Research Endeavor Reveals Cause of Deadly Digestive Disease in Children

Nearly ten years ago, a group of Israeli clinical researchers emailed Berkeley Lab geneticist Len Pennacchio to ask for his team’s help in solving the mystery of a rare inherited disease that caused extreme, and sometimes fatal, chronic diarrhea in children. Now, following an arduous investigative odyssey that expanded our understanding of regulatory sequences in the human genome, the multinational scientific group has announced the discovery of the genetic explanation for this disease.

Berkeley Lab Celebrates the Integrative Genomics Building

Marking a step forward in Berkeley Lab’s vision to expand the footprint of the biological and environmental sciences, the Integrative Genomics Building (IGB) was dedicated during a two-hour ceremony that culminated in the cutting of a double helix ribbon representing DNA. By uniting leading experts and world-class technologies under one roof, the IGB will help transform plant and microbial genomics research into solutions for today’s most pressing environmental and energy issues.

Breakthrough Technique for Studying Gene Expression Takes Root in Plants

An open-source RNA analysis platform has been successfully used on plant cells for the first time – a breakthrough that could herald a new era of fundamental research and bolster efforts to engineer more efficient food and biofuel crop plants. The technology, called Drop-seq, is a method for measuring the RNA present in individual cells, allowing scientists to see what genes are being expressed and how this relates to the specific functions of different cell types.

Mouse Study Yields Long-Awaited Insights into Human Stomach Cancer

Mice have been instrumental in the study of cancer, but like all animal models of human diseases, they have their limitations. For stomach cancer in particular, mice have historically been regarded as quite poor research organisms because rodents rarely develop spontaneous stomach tumors. But results from a new study are about to shake up the paradigm.

Uncovering Uncultivated Microbes in the Human Gut

A human’s health is shaped both by environmental factors and the body’s interactions with the microbiome, particularly in the gut. Genome sequences are critical for characterizing individual microbes and understanding their functional roles. However, previous studies have estimated that only 50 percent of species in the gut microbiome have a sequenced genome, in part because many species have not yet been cultivated for study.

Faster, Cheaper, Better: A New Way to Synthesize DNA

In what could address a critical bottleneck in biology research, Berkeley Lab researchers announced they have pioneered a new way to synthesize DNA sequences through a creative use of enzymes that promises to be faster, cheaper, and more accurate.