Cryo-electron microscopy (cryo-EM)—which enables the visualization of viruses, proteins, and other biological structures at the molecular level—is a critical tool used to advance biochemical knowledge. Now Lawrence Berkeley National Laboratory (Berkeley Lab) researchers have extended cryo-EM’s impact further by developing a new computational algorithm that was instrumental in constructing a 3-D atomic-scale model of bacteriophage
A team of scientists at Berkeley Lab has developed an unsupervised multi-scale machine learning technique that can automatically and specifically capture biomedical events or concepts directly from raw data.
Berkeley Lab researchers have developed a 12-gene score tied to the odds of relapse-free breast cancer survival. The scoring system is based on an analysis of large genomic datasets and patient data, and it could eventually be developed for clinical use.
Berkeley Lab researchers found that the sticky residue left behind by tobacco smoke led to changes in weight and blood cell count in mice. These latest findings add to a growing body of evidence that thirdhand smoke exposure may be harmful.
Berkeley Lab is set to receive $4.6 million over four years as part of an ongoing, federally funded project to create a comprehensive catalog for fundamental genomics research. This latest expansion of the Encyclopedia of DNA Elements (ENCODE) project, or ENCODE 4, is funded by the National Human Genome Research Institute.
Extending the roots of team science at its birthplace, Berkeley Lab will soon bring together researchers from the DOE Joint Genome Institute with those from the Systems Biology Knowledgebase (KBase) under one roof. The groundbreaking for the Integrative Genomics Building (IGB) today celebrates the future colocation of two partnering scientific user community resources and launches construction of the first building in the long-term vision for a consolidated biosciences presence on Berkeley Lab’s main site.
New images are providing the first visual evidence of a long-postulated physical link by which genes can receive mechanical cues from its microenvironment. Created by integrating six different imaging techniques, the images show thread-like cytofilaments reaching into and traversing a human breast cell’s chromatin-packed nucleus.
Berkeley Lab scientists are developing new ways to see the unseen. Here are seven imaging advances (recently reported in our News Center) that are helping to push science forward, from developing better batteries to peering inside cells to exploring the nature of the universe. 1. Seeing DNA nanostructures in 3-D DNA segments can serve as a
Scientists from Berkeley Lab and PNNL have found that genes and early environment play big roles in shaping the gut microbiome. The microbes retained a clear “signature” formed where the mice were first raised, and the characteristics carried over to the next generation. The findings could potentially be used to develop designer diets optimized to an individual’s microbiome.
An international team of scientists is providing new insight into the process by which plants use light to split water and create oxygen. In experiments led by Berkeley Lab scientists, ultrafast X-ray lasers were able to capture atomic-scale images of a protein complex found in plants, algae, and cyanobacteria at room temperature.